RELATIONSHIPS BETWEEN ROTATOR CUFF STRENGTH PARAMETERS AND THROWING VELOCITY OF COLLEGE BASEBALL PLAYERS

Pitching a baseball is a complex, highly skilled movement that has been divided into four stages by sports researchers. In examining the throwing motion, researchers have: 1) attempted to find the most significant muscle groups of the upper extremity that contribute to throwing velocity (Jobe, 1987; Pedegna, 1982 and Toyoshima and Hoshikawa, 1974); 2) concluded that the shoulder and internal and external rotator groups are the most significant contributors to the throwing motion (Alderink and Kuck, 1986; Cain, Mutschler, Fu and Lee, 1987, Cook, Gray, Savinar-Nogue, Medeiros, 1987, and Pappas, Zawacki and MacCarthy, 1985); and 3) demonstrated that the motions of shoulder rotation are important during tht throwing performance (Atwater, Feltner and Dapena, 1986; Gainor, 1980; and Tullos and King, 1973)

The gas–liquid phase-transition singularities in the framework of the liquid-state integral equation formalism

6 pages, 4 figures.-- PACS: 64.70.Fx; 65.20.+w; 02.30.Rz; 62.10.+sThe singularities of various liquid-state integral equations derived from the Ornstein–Zernike relation and its temperature derivatives, have been investigated in the liquid–vapor transition region. As a general feature, it has been found that the existence of a nonsolution curve on the vapor side of the phase diagram, on which both the direct and the total correlation functions become complex—with a finite isothermal compressibility—also corresponds to the locus of points where the constant-volume heat capacity diverges, in consonance with a divergence of the temperature derivative of the correlation functions. In contrast, on the liquid side of the phase diagram one finds that a true spinodal (a curve of diverging isothermal compressibilities) is reproduced by the Percus–Yevick and Martynov–Sarkisov integral equations, but now this curve corresponds to states with finite heat capacity. On the other hand, the hypernetted chain approximation exhibits a nonsolution curve with finite compressibilities and heat capacities in which, as temperature is lowered, the former tends to diverge.E.L. acknowledges financial support of the Dirección General de Investigación Científica y Técnica under Grant No. FIS2004-02954-C03-01. This work has been carried out under the auspices of the exchange agreement between the Consejo Superior de Investigaciones Científicas and the Russian Academy of Sciencies, which supported the exchange visits of E.L. and G.S. in the past two years.Peer reviewe

Інвестиційна політика як один з пріорітетних шляхів розвитку економіки регіонів

В сучасних умовах спаду економічного розвитку регіонів важливу роль відіграють пошуки нових напрямів в регіональній реформі. На сучасному етапі дуже мало приділяється уваги новаторським питанням. Таким чином, розвиток інноваційної діяльності суб’єктів господарювання регіону може бути використаний як дієвий чинник економічного оздоровлення

Bursty egocentric network evolution in Skype

In this study we analyze the dynamics of the contact list evolution of millions of users of the Skype communication network. We find that egocentric networks evolve heterogeneously in time as events of edge additions and deletions of individuals are grouped in long bursty clusters, which are separated by long inactive periods. We classify users by their link creation dynamics and show that bursty peaks of contact additions are likely to appear shortly after user account creation. We also study possible relations between bursty contact addition activity and other user-initiated actions like free and paid service adoption events. We show that bursts of contact additions are associated with increases in activity and adoption - an observation that can inform the design of targeted marketing tactics.Comment: 7 pages, 6 figures. Social Network Analysis and Mining (2013

Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer.

Expression of the oncogenic transcription factor MYC is disproportionately elevated in triple-negative breast cancer (TNBC), as compared to estrogen receptor-, progesterone receptor- or human epidermal growth factor 2 receptor-positive (RP) breast cancer. We and others have shown that MYC alters metabolism during tumorigenesis. However, the role of MYC in TNBC metabolism remains mostly unexplored. We hypothesized that MYC-dependent metabolic dysregulation is essential for the growth of MYC-overexpressing TNBC cells and may identify new therapeutic targets for this clinically challenging subset of breast cancer. Using a targeted metabolomics approach, we identified fatty acid oxidation (FAO) intermediates as being dramatically upregulated in a MYC-driven model of TNBC. We also identified a lipid metabolism gene signature in patients with TNBC that were identified from The Cancer Genome Atlas database and from multiple other clinical data sets, implicating FAO as a dysregulated pathway that is critical for TNBC cell metabolism. We found that pharmacologic inhibition of FAO catastrophically decreased energy metabolism in MYC-overexpressing TNBC cells and blocked tumor growth in a MYC-driven transgenic TNBC model and in a MYC-overexpressing TNBC patient-derived xenograft. These findings demonstrate that MYC-overexpressing TNBC shows an increased bioenergetic reliance on FAO and identify the inhibition of FAO as a potential therapeutic strategy for this subset of breast cancer

Развитие подхода к моделированию процесса получения этилбензола

На примере процесса синтеза этилбензола предложен подход к формализации схемы превращений углеводородов, заключающийся в группировании компонентов по их реакционной способности в отношении определенной реакции. Рассчитаны значения степеней компенсации реакций как показателя реакционной способности компонентов. Разработаны кинетические модели процессов алкилирования бензола этиленом и трансалкилирования полиалкилатов

Multiscale Analysis of Spreading in a Large Communication Network

In temporal networks, both the topology of the underlying network and the timings of interaction events can be crucial in determining how some dynamic process mediated by the network unfolds. We have explored the limiting case of the speed of spreading in the SI model, set up such that an event between an infectious and susceptible individual always transmits the infection. The speed of this process sets an upper bound for the speed of any dynamic process that is mediated through the interaction events of the network. With the help of temporal networks derived from large scale time-stamped data on mobile phone calls, we extend earlier results that point out the slowing-down effects of burstiness and temporal inhomogeneities. In such networks, links are not permanently active, but dynamic processes are mediated by recurrent events taking place on the links at specific points in time. We perform a multi-scale analysis and pinpoint the importance of the timings of event sequences on individual links, their correlations with neighboring sequences, and the temporal pathways taken by the network-scale spreading process. This is achieved by studying empirically and analytically different characteristic relay times of links, relevant to the respective scales, and a set of temporal reference models that allow for removing selected time-domain correlations one by one

Circadian pattern and burstiness in mobile phone communication

The temporal communication patterns of human individuals are known to be inhomogeneous or bursty, which is reflected as the heavy tail behavior in the inter-event time distribution. As the cause of such bursty behavior two main mechanisms have been suggested: a) Inhomogeneities due to the circadian and weekly activity patterns and b) inhomogeneities rooted in human task execution behavior. Here we investigate the roles of these mechanisms by developing and then applying systematic de-seasoning methods to remove the circadian and weekly patterns from the time-series of mobile phone communication events of individuals. We find that the heavy tails in the inter-event time distributions remain robustly with respect to this procedure, which clearly indicates that the human task execution based mechanism is a possible cause for the remaining burstiness in temporal mobile phone communication patterns.Comment: 17 pages, 12 figure